YHEC offers a range of services to inform the development and conduct of indirect and mixed treatment comparisons (ITC and MTC).

What are Indirect and Mixed Treatment Comparisons?

Indirect and mixed treatment comparisons (network meta-analyses, NMA) are statistical tools for assessing, for example, the comparative efficacy and safety of interventions when:

    • There is no direct evidence between the interventions of interest,
    • There is insufficient direct evidence or
    • There are more than two interventions that need to be compared.

NMA methods are developing quickly and are already being widely used in health care to inform decisions which require an understanding of the comparative effectiveness of different treatments, devices and diagnostic techniques.


Examples of Recent Publications

View other recent research projects on our publications page


YHEC training

Find out more about our Indirect and Mixed Treatment Comparisons Training

YHEC training